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Case Reports
. 2005 Sep;31(9):1235-8.
doi: 10.1007/s00134-005-2718-x. Epub 2005 Jul 22.

Elevated carboxyhemoglobin associated with sodium nitroprusside treatment

Jesús López-Herce  1 , Raúl Borrego, Amaya Bustinza, Angel Carrillo
Affiliations
Case Reports

Elevated carboxyhemoglobin associated with sodium nitroprusside treatment

Jesús López-Herce et al. Intensive Care Med. 2005 Sep.

Abstract

Objective: To report four cases of carboxyhemoglobinemia associated with high doses of sodium nitroprusside after cardiac transplant in children.

Patients: Four children in the pediatric care unit of a university hospital aged 6 months-4 years. Carboxyhemoglonemia developed at levels of 5.5-7.7% in patients receiving high doses of sodium nitroprusside (7-16 microg/kg per minute and no other medication that could caused elevated carboxyhemoglobin). One patient died, and three recovered with no sequelae after discontinuation of sodium nitroprusside.

Conclusions: High doses of sodium nitroprusside can induce carboxyhemoglobinemia in children after heart transplant, probably by inducing hemeoxygenase, with no other secondary effects.

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