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. 2005 Aug 15;39(5):632-4.

Longitudinal assessment of HIV-1 and HSV-2 shedding in the genital tract of West African women

Nicolas Nagot  1 , Vincent Foulongne, Pierre Becquart, Philippe Mayaud, Issouf Konate, Abdoulaye Ouedraogo, Marie-Christine Defer, Helen Weiss, Philippe Van de Perre, Michel Segondy
Affiliations
  • PMID: 16044019

Longitudinal assessment of HIV-1 and HSV-2 shedding in the genital tract of West African women

Nicolas Nagot et al. J Acquir Immune Defic Syndr. .

Abstract

Forty-two HSV-2-seropositive women, of whom 22 were HIV-1 seropositive, were followed up weekly for 3 weeks for assessment of HIV-1 and HSV-2 genital shedding in Bobo Dioulasso, Burkina Faso. HSV-2 DNA and HIV-1 RNA were quantitated in cervicovaginal lavages enriched with a cervical swabbing (eCVL) using real-time polymerase chain reaction. HIV-1 RNA shedding was detected in eCVL from 19 of 22 (86.4%) of the HIV-1-seropositive women and HSV-2 DNA was detected in eCVL from 12 of 42 (28.6%) of the women. Compared with the HIV-1-seronegative women, the HIV-1-seropositive women showed more persistent HSV-2 genital shedding and higher HSV-2 DNA loads in eCVL. This study showed that eCVL is a reliable sampling method for detecting both viruses. Three measurement points (at weekly intervals in this study) seem to adequately allow detection of most HIV-1 or HSV-2 genital shedders.

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