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Clinical Trial
. 2005 Jun;30(3):299-303.

[Quality of life in the treatment assessment of postmenopausal osteoporosis]

[Article in Chinese]
Yu-Feng Hu  1 , Zhen-Qiu Sun
Affiliations
  • PMID: 16045018
Clinical Trial

[Quality of life in the treatment assessment of postmenopausal osteoporosis]

[Article in Chinese]
Yu-Feng Hu et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Jun.

Abstract

Objective: To evaluate quality of life (QOL) in the treatment assessment of postmenopausal osteoporosis (PMOP) by comparing the QOL of three treatments: hormone replacement treatment, supplement of calcium and vitamin D and risedronate.

Methods: All patients with postmenopausal osteoporosis (PMOP) in this clinical trial had been allocated into 4 groups: placebo therapy group, vitamin D addition calcium therapy group, hormone replacement treatment (HRT) therapy group, and risedronate therapy group. We measured the bone mineral density (BMD) and quality of life sale (QOLS) of patients in three times, before the treatment, 3 months after the treatment,and 12 months after the treatment. The differences of the QOL and BMD at the 4 groups and at different time, the linear correlation of the change of QOL and the change of BMD, were both compared after the measurement.

Results: The total score of QOL and the score of disease domain and physical domain of HRT therapy group and risedronate therapy group were higher than the placebo therapy group (F = 17. 335, P <0.001), but vitamin D addition calcium therapy group was not different from that of the placebo therapy group. The score of other three domains had no statistically significant difference among the 4 groups. The score of disease domain of the patients of risedronate therapy group started to increase after 3 months of treatment, and continued to increase after 12 months of treatment. The score of disease domain of the patients of HRT therapy group started to increase only after 12 months of treatment. But the score of disease domain of the patients of vitamin D addition calcium therapy group did not increase after 12 months of treatment. The changes of the score of disease domain had the linar correlation with the changes of BMD, and the correlation coefficient was from 0.608 to 0.827.

Conclusion: QOL may become one of the indexes of medical treatment outcome assessment system for PMOP.

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