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. 2006 Mar;100(3):512-8.
doi: 10.1016/j.rmed.2005.06.001. Epub 2005 Jul 25.

Childhood respiratory infections and hospital admissions for COPD

T E McManus  1 , P V Coyle, J C Kidney
Affiliations

Childhood respiratory infections and hospital admissions for COPD

T E McManus et al. Respir Med. 2006 Mar.

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) exacerbations are associated with viral infections. We wished to determine if respiratory viral infection of children in the community was associated with hospital admissions of patients with exacerbations of COPD.

Methods: We collected data over a 45-month period from the Northern Ireland Regional Virus Laboratory and from a general hospital in the same locality. We studied the relationship between upper respiratory infections in children and COPD admissions. We also examined the role of school holidays.

Results: Correlations were seen between the frequency of all viral infections in children and the number of adult COPD hospitalizations (P<0.005). Subgroup analysis showed distinct relationships with epidemics of; influenza A (P<0.001), influenza B (P<0.05), adenovirus (P=0.05), respiratory syncytial virus (P<0.005) and hospital admissions of patients with COPD. There were significantly fewer COPD admissions in the week after the start of a school holiday period (P<0.05).

Conclusions: When children are hospitalized with viral respiratory infection there is an associated rise in adult COPD admissions. This suggests exacerbations of COPD are associated with epidemics of respiratory viruses. When children are on school holidays there is a reduction in COPD admissions in the community. This provides further support for respiratory viruses in the pathogenesis of COPD exacerbations.

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Figures

Figure 1
Figure 1
COPD admissions and virus detection during the study.
Figure 2
Figure 2
COPD admissions and total numbers of respiratory viruses seen in children. The admissions are illustrated by bars, each bar represents 1 week and the left Y-axis shows the range. Viruses detected in children are shown as a solid line; the right Y-axis shows the range.
See this image and copyright information in PMC

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