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Comment
. 2005 Aug 2;102(31):10759-60.
doi: 10.1073/pnas.0504965102. Epub 2005 Jul 26.

Obesity and metabolic perturbations after loss of aquaporin 7, the adipose glycerol transporter

Ormond A MacDougald  1 , Charles F Burant
Affiliations
Comment

Obesity and metabolic perturbations after loss of aquaporin 7, the adipose glycerol transporter

Ormond A MacDougald et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
A loss of glycerol export from adipocytes causes alterations to the triglyceride/fatty acid cycle and perturbations in glucose homeostasis. The phenotype of young Aqp7-/- mice is relatively mild, characterized by fasting-induced hypoglycemia. In older mice, a loss of glycerol transport results in a dramatic accumulation of triacylglycerol in adipose tissue and metabolic alterations, including elevated FFA, hyperglycemia, and insulin resistance. Red arrows indicate metabolic perturbations in Aqp7-/- mice or in mice with reduced expression of Aqp7 in 3T3-L1 adipocytes. [Modified from Reshef et al. (6).]
See this image and copyright information in PMC

Comment on

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