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. 2005 Aug 4;7(16):3573-5.
doi: 10.1021/ol0513903.

Conjugated polymer-based fluorescence turn-on sensor for nitric oxide

Rhett C Smith  1 , Andrew G Tennyson, Mi Hee Lim, Stephen J Lippard
Affiliations

Conjugated polymer-based fluorescence turn-on sensor for nitric oxide

Rhett C Smith et al. Org Lett. .

Abstract

A turn-on fluorescent sensor for NO (g) in solution was synthesized using a bipyridyl-substituted poly(p-phenylene vinylene) derivative (CP1) as the sensory scaffold. The action of NO (g) upon the CP1-Cu(II) complex reduces it to the CP1-Cu(I) complex with a concomitant 2.8-fold increase in emission intensity. The reagent is selective for NO (g) versus other biological reactive nitrogen species, except for nitroxyl, and has a detection sensitivity limit of 6.3 nM. [structure: see text]

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Figures

Figure 1
Figure 1
Structure of CP1.
Figure 2
Figure 2
Emission spectra of CP1 (black), CP1–Cu(I) (green), CP1–Cu(II) (red), and CP1–Cu(II) immediately following addition of 300 equiv of NO (g). All measurements were made in 4:1 CH2Cl2/EtOH.
Scheme 1
Scheme 1
Strategies for Fluorescent Detection of Nitric Oxide
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