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. 2005 Aug;49(8):3538-40.
doi: 10.1128/AAC.49.8.3538-3540.2005.

First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-beta-lactamase (VIM-2) in the United States

K Lolans  1 , A M Queenan, K Bush, A Sahud, J P Quinn
Affiliations

First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-beta-lactamase (VIM-2) in the United States

K Lolans et al. Antimicrob Agents Chemother. 2005 Aug.

Abstract

Carbapenemases are rare in the United States. This is the first report of a United States nosocomial outbreak of pan-resistant Pseudomonas aeruginosa infections due to an integron-borne metallo-beta-lactamase, VIM-2. This emergence of carbapenemases on mobile genetic elements in the United States warrants surveillance.

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Figures

FIG. 1.
FIG. 1.
PFGE of XbaI-digested chromosomal DNA. Lanes 1 and 8, lambda markers; lane 2, P. aeruginosa 7052; lane 3, case no. 2; lane 4, case no. 3; lane 5, case no. 4; lane 6, case no. 5; lane 7, case no. 6.
FIG. 2.
FIG. 2.
Genetic context of blaVIM-2-containing integron fragment from P. aeruginosa 7052. Schematic structure (not to scale) of the 4.45-kb BamHI plasmid insert. Open reading frames of the various resistance genes and the transcriptional orientation are represented by arrows. Percent homologies are to the GenBank sequences listed in the text.
See this image and copyright information in PMC

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