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. 2005 Aug 22;93(4):450-2.
doi: 10.1038/sj.bjc.6602717.

Positive thyroid transcription factor 1 staining strongly correlates with survival of patients with adenocarcinoma of the lung

F Barlési  1 , D Pinot, A Legoffic, C Doddoli, B Chetaille, J-P Torre, P Astoul
Affiliations

Positive thyroid transcription factor 1 staining strongly correlates with survival of patients with adenocarcinoma of the lung

F Barlési et al. Br J Cancer. .

Abstract

This study investigated the relation between positive thyroid transcription factor 1 (TTF1) staining and survival of patients affected by primary adenocarcinoma (ADC) of the lung. Pathological tissue from consecutive ADC patients was collected from 2002 to 2004. The anti-TTF1 antibody (8G7G3/1, dilution of 1/200) was used. Thyroid transcription factor 1 staining was assessed for each tumour as positive or negative. Probability of survival was estimated by Kaplan-Meier and difference tested by log-rank test. A Cox's regression multivariate analysis was carried out. In all, 106 patients were studied (66% male, 69% PS0-1, 83% with stage III or IV). Tumours expressed positive TTF1 staining in 66% of cases. Multivariate analysis demonstrated an independent lower risk of death for patients whose tumour expresses positive TTF1 staining (HR = 0.51, 95% CI 0.30-0.85; P = 0.01) and higher grade of differentiation (HR = 0.40, 95% CI 0.24-0.68; P = 0.001). In conclusion, positive TTF1 staining strongly and independently correlates with survival of patients with primary ADC of the lung.

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Figures

Figure 1
Figure 1
Survival curves of patients whose tumours showed positive and negative TTF1 staining.
Figure 2
Figure 2
Acinar ADC (haematoxylin and eosin, × 100) (A) showing positive nuclear TTF1 staining (B), and acinar ADC (haematoxylin and eosin, × 100) (C) showing negative TTF1 staining (D).
See this image and copyright information in PMC

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