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. 2006 Jul;20(7):801-4.
doi: 10.1038/sj.eye.6702011. Epub 2005 Jul 22.

Vitreous leptin levels in retinal disease

D Maberley  1 , J Z Cui, J A Matsubara
Affiliations

Vitreous leptin levels in retinal disease

D Maberley et al. Eye (Lond). 2006 Jul.

Abstract

Background/aims: The purpose of this study was to investigate the relationship between vitreous leptin levels and retinal diseases.

Methods: Levels of vitreous leptin were evaluated in proliferative diabetic retinopathy (PDR) and a variety of other retinopathies including: macular disease, neovascular maculopathies, primary retinal detachments, and vascular occlusive disease.

Results: In patients with PDR (N=7), the average vitreous level of leptin (37.4 ng/ml) was significantly higher than that in patients with PVR (<1.0 ng/ml, P<0.05). Vitreous leptin level in patients with PVR or macular disease (N=18), with or without diabetes, was not significantly different from the control subjects who had retinal detachment only (N=7).

Conclusion: The results show that the leptin level in vitreous taps is elevated in PDR. We suggest that leptin plays an active role in PDR.

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