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. 2005 Aug 7;11(29):4536-40.
doi: 10.3748/wjg.v11.i29.4536.

Characteristics of benign lymphoadenosis of oral mucosa

Shu-Xia Li  1 , Shi-Feng Yu, Kai-Hua Sun
Affiliations

Characteristics of benign lymphoadenosis of oral mucosa

Shu-Xia Li et al. World J Gastroenterol. .

Abstract

Aim: To investigate the pathological characteristics and carcinogenesis mechanism of benign lymphoadenosis of oral mucosa (BLOM).

Methods: The expressions of Ki-67, CD34 and apoptosis were evaluated by immunohistochemical SP staining in 64 paraffin-embedded tissue samples. Of them, 9 were from BLOM with dysplasia, 15 from BLOM without dysplasia, 15 from oral squamous cell carcinoma (OSCC), 15 from oral precancerosis, and 10 from normal tissues. Cell proliferation, apoptosis and angiogenesis of tissue samples were also analyzed.

Results: The expression of Ki-67 in BLOM with dysplasia, oral precancerosis and OSCC was significantly higher than in BLOM without dysplasia and normal mucosa. The microvascular density (MVD) in BLOM with and without dysplasia, oral precancerosis, and OSCC was significantly higher than in normal mucosa. Apoptosis in BLOM and oral precancerosis was significantly higher than in OSCC and normal mucosa.

Conclusion: Benign lymphoadenosis of oral mucosa has potentialities of cancerization.

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Figures

Figure 1
Figure 1
Ki-67 expression in A: BLOM without dysplasia (IHC ×400), B: BLOM with dysplasia (IHC ×200), and C: oral cancer (IHC ×200).
Figure 2
Figure 2
CD34 expression in A: BLOM without dysplasia (IHC ×100) and B: BLOM with dysplasia (IHC ×100).
Figure 3
Figure 3
Apoptosis in BLOM with dysplasia (TUNEL ×200).
See this image and copyright information in PMC

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References

    1. Sun KH, Wu QG, Zheng LF. Clinicopathological analysis of 70 cases of benign lymphoadenosis of oral mucosa. Zhonghua Kouqiang Yixue Zazhi. 1986;21:137–139. - PubMed
    1. Sun KH, Yu SF, Wu QG, Zheng LF, Wei MJ. Ultrastructural and immunopathological study of benign lymphoadenosis of oral mucosa. Zhonghua Kouqiang Yixue Zazhi. 1992;27:104–106. - PubMed
    1. Harsany DL, Ross J, Fee WE. Follicular lymphoid hyperplasia of the hard palate simulating lymphoma. Otolaryngol Head Neck Surg. 1980;88:349–356. - PubMed
    1. Wright JM, Dunsworth AR. Follicular lymphoid hyperplasia of the hard palate: a benign lymphoproliferative process. Oral Surg Oral Med Oral Pathol. 1983;55:162–168. - PubMed
    1. Yu SF. Kouqiang Zuzhi Binglixue(5th edition) Beijing: People抯 health publishing house; 2003. pp. 203–204.