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Comparative Study
. 2005 Jun;22(2):129-32.
doi: 10.1007/s11083-005-9013-x.

Association of HLA DQB1 0602 in sarcoidosis patients with small fiber neuropathy

Christina E M Voorter  1 , Marjolein Drent, Elske Hoitsma, Karin G Faber, Ella M van den Berg-Loonen
Affiliations
Comparative Study

Association of HLA DQB1 0602 in sarcoidosis patients with small fiber neuropathy

Christina E M Voorter et al. Sarcoidosis Vasc Diffuse Lung Dis. 2005 Jun.

Abstract

Background and aim: Sarcoidosis has been reported to be associated with the HLA genes, in particular DQB1.

Methods: High resolution DQB 1 of 103 sarcoidosis patients was obtained by sequence-based typing; low resolution HLA-A/B/DRB 1 typing was performed by serological and molecular methods. Small fiber neuropathy (SFN) was established by thermal threshold testing.

Results: Sixty-seven patients suffered from SFN (SFN+), in 36 patients SFN was absent (SFN-). Comparing HLA DQB 1 typings of SFN+ patients, SFN- patients and control individuals revealed a significant increase of the allele DQB 1 0602 in SFN+ patients compared to controls.

Conclusion: This association might be correlated with a severe course of the disease.

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