Comment
doi: 10.1016/j.cmet.2005.03.008.
All roads lead to FoxO
Affiliations
- PMID: 16054064
- DOI: 10.1016/j.cmet.2005.03.008
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Comment
All roads lead to FoxO
Cell Metab.
2005 Apr.
Free article
Abstract
Stress-activated kinases control metabolism by antagonizing the early steps of insulin signal transduction. Two papers now demonstrate that Jnk, the prototypical stress-activated kinase, controls life span in Drosophila and C. elegans by promoting phosphorylation of the forkhead protein FoxO (Oh et al., 2005; Wang et al., 2005). The findings provide yet another mechanism by which metabolic and stress responses are integrated via phosphorylation of FoxO proteins.
Comment on
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JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4494-9. doi: 10.1073/pnas.0500749102. Epub 2005 Mar 14. Proc Natl Acad Sci U S A. 2005. PMID: 15767565 Free PMC article.
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JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling.Cell. 2005 Apr 8;121(1):115-25. doi: 10.1016/j.cell.2005.02.030. Cell. 2005. PMID: 15820683
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