Energizer: PGC-1 alpha keeps the heart going
- PMID: 16054065
- DOI: 10.1016/j.cmet.2005.03.009
Energizer: PGC-1 alpha keeps the heart going
Abstract
In the current issue of Cell Metabolism, Arany et al. (2005) demonstrate essential roles for PGC-1alpha in cardiac metabolism, proving several long-postulated functions while disproving others. These experiments conclusively reinforce the logic of rescuing PGC-1alpha as a novel therapeutic target in heart failure.
Comment on
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Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.Cell Metab. 2005 Apr;1(4):259-71. doi: 10.1016/j.cmet.2005.03.002. Cell Metab. 2005. PMID: 16054070
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