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Review
. 2005 May;1(5):290-2.
doi: 10.1016/j.cmet.2005.04.006.

Dual regulation of the LDL receptor--some clarity and new questions

Alan D Attie  1 , Nabil G Seidah
Affiliations
Free article
Review

Dual regulation of the LDL receptor--some clarity and new questions

Alan D Attie et al. Cell Metab. 2005 May.
Free article

Abstract

Upregulation of the expression of the LDL receptor (LDLR) gene does not always lead to an increase in the LDLR protein. While the mRNA expression of the LDLR and the newly studied proprotein convertase PCSK9 are coordinately upregulated in absence of sterols, the latter proteinase apparently enhances the degradation of the LDLR protein.

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