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Comment
. 2005 Jun;1(6):357-8.
doi: 10.1016/j.cmet.2005.05.006.

ROS: really involved in oxygen sensing

William G Kaelin Jr  1
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Free article
Comment

ROS: really involved in oxygen sensing

William G Kaelin Jr. Cell Metab. 2005 Jun.
Free article

Abstract

The role of reactive oxygen species (ROS) in the cellular response to cellular oxygen sensing has been controversial. Three papers in this issue of Cell Metabolism (Brunelle et al., Guzy et al., 2005; Mansfield et al., 2005) used genetic tools to establish that ROS produced by mitochondria are required for the normal induction of HIF (hypoxia-inducible factor), which is a master regulator of oxygen-sensitive gene expression, by low oxygen.

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