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Clinical Trial
. 2005 Nov 15;79(2-3):337-40.
doi: 10.1016/j.schres.2005.06.015. Epub 2005 Jul 28.

A retrospective comparison of cumulative time spent in remission during treatment with olanzapine or risperidone among patients with schizophrenia

Gopalan Sethuraman  1 , Cindy C Taylor, Mark Enerson, Eduardo Dunayevich
Affiliations
Clinical Trial

A retrospective comparison of cumulative time spent in remission during treatment with olanzapine or risperidone among patients with schizophrenia

Gopalan Sethuraman et al. Schizophr Res. .

Abstract

Background: Available studies suggest comparable efficacy of olanzapine and risperidone for the treatment of schizophrenia over the short term.

Method: This retrospective analysis of data from a 28-week, double-blind, schizophrenia trial compared the cumulative amount of time that patients met severity criteria for remission during olanzapine (10-20 mg/day) or risperidone (4-12 mg/day) treatment.

Results: The percentage cumulative time spent in remission was 40% for olanzapine- and 31% for risperidone-treated patients (P = 0.03) using Definition 1 (PANSS items P1, P2, P3, N1, N4, N6, G5, G9 < or = 3), and 18% and 11% (P = 0.01), respectively, using Definition 2 (BPRS Total reduced 50%, BPRS psychosis items < or = 3, CGI-severity < or = 3).

Conclusion: During 28 weeks of treatment, olanzapine-treated patients spent more cumulative time in remission than risperidone-treated patients.

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