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Review
. 2005 Sep;18(3):383-95, vi.
doi: 10.1016/j.ohc.2005.04.002.

Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies

Markus H Kuehn  1 , John H Fingert, Young H Kwon
Affiliations
Review

Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies

Markus H Kuehn et al. Ophthalmol Clin North Am. 2005 Sep.

Abstract

Various cellular and molecular mechanisms that may lead to apoptotic cell death of retinal ganglion cells in glaucoma are discussed. These cellular mechanisms include neurotrophic factor deprivation, ischemia, glial cell activation, glutamate excitotoxicity, and abnormal immune response. Based on experimental and clinical evidence, the rationale for various neuroprotective strategies is described.

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