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Comparative Study
. 1992 Feb;36(2):477-80.
doi: 10.1128/AAC.36.2.477.

Effect of cyclodextrin on the pharmacology of antifungal oral azoles

J S Hostetler  1 , L H Hanson, D A Stevens
Affiliations
Comparative Study

Effect of cyclodextrin on the pharmacology of antifungal oral azoles

J S Hostetler et al. Antimicrob Agents Chemother. 1992 Feb.

Abstract

Concentrations of oral azoles in serum were compared in a single-dose pharmacologic study in mice. When hydroxypropyl-beta-cyclodextrin was used as a carrier and compared with a standard carrier, polyethylene glycol, drug concentrations determined by bioassay showed that the peak concentration and area under the concentration-time curve were greatly enhanced for itraconazole and saperconazole; moderately enhanced for ketoconazole; but negligibly affected for fluconazole, miconazole, and SCH 42427.

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