Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1992 Feb;36(2):477-80.
doi: 10.1128/AAC.36.2.477.

Effect of cyclodextrin on the pharmacology of antifungal oral azoles

J S Hostetler  1 , L H Hanson, D A Stevens
Affiliations
Comparative Study

Effect of cyclodextrin on the pharmacology of antifungal oral azoles

J S Hostetler et al. Antimicrob Agents Chemother. 1992 Feb.

Abstract

Concentrations of oral azoles in serum were compared in a single-dose pharmacologic study in mice. When hydroxypropyl-beta-cyclodextrin was used as a carrier and compared with a standard carrier, polyethylene glycol, drug concentrations determined by bioassay showed that the peak concentration and area under the concentration-time curve were greatly enhanced for itraconazole and saperconazole; moderately enhanced for ketoconazole; but negligibly affected for fluconazole, miconazole, and SCH 42427.

PubMed Disclaimer

References

    1. Antimicrob Agents Chemother. 1991 May;35(5):846-50 - PubMed
    1. Ann Intern Med. 1991 May 1;114(9):755-7 - PubMed
    1. J Am Acad Dermatol. 1987 Aug;17(2 Pt 1):220-3 - PubMed
    1. Antimicrob Agents Chemother. 1982 Jan;21(1):151-8 - PubMed
    1. Am J Med. 1989 Jun;86(6 Pt 2):791-800 - PubMed

Publication types

LinkOut - more resources