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. 1992 May;11(4):315-20.
doi: 10.1089/dna.1992.11.315.

Structure and expression of mouse alpha 1-acid glycoprotein gene-3 (AGP-3)

C J Chang  1 , M Y Lai, D S Chen, S C Lee
Affiliations

Structure and expression of mouse alpha 1-acid glycoprotein gene-3 (AGP-3)

C J Chang et al. DNA Cell Biol. 1992 May.

Abstract

The genome of Mus domesticus has multiple genes of the alpha 1-acid glycoprotein (AGP). Two cDNA clones were identified corresponding to AGP-1 and AGP-2. Moreover, two alleles of AGP-1 exist in inbred mice. The genomic DNA of the AGP-2 gene has been cloned and studied. Here we report the genomic organization of three M. domesticus AGP genes, the sequence analysis of the AGP-3 genomic DNA, and the expression of the AGP-3 gene. The major structural differences between AGP-2 and AGP-3 genes are located in introns 1 and 5. The low level of AGP-3 mRNA can be detected by the polymerase chain reaction (PCR). The molecular basis of the low level expression of AGP-3 and the possible classification of AGP-3 as a pseudogene are discussed.

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