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Case Reports
. 1992 Mar-Apr;7(2):162-5.
doi: 10.2165/00002018-199207020-00008.

Spontaneous fractures in a patient treated with low doses of etidronic acid (disodium etidronate)

K S Eyres  1 , P Marshall, E McCloskey, D L Douglas, J A Kanis
Affiliations
Case Reports

Spontaneous fractures in a patient treated with low doses of etidronic acid (disodium etidronate)

K S Eyres et al. Drug Saf. 1992 Mar-Apr.

Abstract

The recommended regimen of etidronic acid (disodium etidronate) for the treatment of Paget's disease of bone is 5mg/kg/day for a period of less than six months. There have, however, been reports of impaired mineralisation of bone and concern that the risk of fracture is increased with this dosage. We report a patient with Paget's disease in whom fractures occurred through pagetic and non-pagetic bone which appeared to be causally related to treatment with lose doses of etidronic acid. The osteomalacia resolved when etidronic acid was discontinued.

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