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. 2005 Mar-Apr;5(2):45-51.
doi: 10.1111/j.1535-7597.2005.05201.x.

Using current evidence in selecting antiepileptic drugs for use during pregnancy

Page B Pennell  1
Affiliations

Using current evidence in selecting antiepileptic drugs for use during pregnancy

Page B Pennell. Epilepsy Curr. 2005 Mar-Apr.

Abstract

Children born to mothers taking antiepileptic drugs (AEDs) are at increased risk for findings of fetal anticonvulsant syndrome. Accepted treatment paradigms to minimize fetal risks include use of AED monotherapy and folic acid supplementation. However, as data are acquired from several ongoing pregnancy registries, differential risks among the various AED monotherapy regimens are being defined, further improving fetal outcomes.

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Figures

FIGURE 1
FIGURE 1
Reported average major malformation rates (%) by specific monotherapy exposures in utero. WWE, women with epilepsy; AEDS, antiepileptic drugs; PB, phenobarbital; PRM, primidone; PHT, phenytoin; CBZ, carbamazepine; VPA, valproate; LTG, lamotrigine.
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