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Comment
. 2005 Aug 5;19(3):294-6.
doi: 10.1016/j.molcel.2005.07.008.

Saving the ends for last: the role of pol mu in DNA end joining

Tanya T Paull  1
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Saving the ends for last: the role of pol mu in DNA end joining

Tanya T Paull. Mol Cell. .
Free article

Abstract

At least three DNA polymerases participate in nonhomologous end joining in mammalian cells: pol mu, pol kappa, and TdT. A study in this issue of Molecular Cell (Nick McElhinny et al., 2005) clarifies the role of pol mu in end joining at the kappa light chain locus and also provides a biochemical explanation for the unique polymerization functions of pol mu on DNA ends.

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