Review
doi: 10.1016/0005-2760(92)90210-m.
Activator proteins and topology of lysosomal sphingolipid catabolism
Affiliations
- PMID: 1606169
- DOI: 10.1016/0005-2760(92)90210-m
Item in Clipboard
Review
Activator proteins and topology of lysosomal sphingolipid catabolism
Biochim Biophys Acta.
.
Abstract
The lysosomal degradation of several sphingolipids by acid hydrolases is dependent on small non-enzymic cofactors, called sphingolipid activator proteins some of which have been identified as sphingolipid binding proteins. This review summarizes the information available on the structure, function, biosynthesis, gene organization and pathobiochemistry of the known sphingolipid activator proteins. It also offers models for their mode of action and for the topology of lysosomal digestion of glycolipids.
Similar articles
-
Sphingolipid metabolism. Sphingoid analogs, sphingolipid activator proteins, and the pathology of the cell.Ann N Y Acad Sci. 1998 Jun 19;845:139-51. doi: 10.1111/j.1749-6632.1998.tb09667.x. Ann N Y Acad Sci. 1998. PMID: 9668348 Review.
-
Metabolism of glycolipids: the role of glycolipid-binding proteins in the function and pathobiochemistry of lysosomes.Biochem Soc Trans. 1992 Aug;20(3):695-9. doi: 10.1042/bst0200695. Biochem Soc Trans. 1992. PMID: 1426613 Review. No abstract available.
-
Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids.Annu Rev Cell Dev Biol. 2005;21:81-103. doi: 10.1146/annurev.cellbio.21.122303.120013. Annu Rev Cell Dev Biol. 2005. PMID: 16212488 Review.
-
[Disorders of sphingolipid activator proteins].Nihon Rinsho. 1995 Dec;53(12):3025-7. Nihon Rinsho. 1995. PMID: 8577053 Review. Japanese.
-
Stimulation of lysosomal sphingomyelin degradation by sphingolipid activator proteins.Chem Phys Lipids. 1999 Nov;102(1-2):35-43. doi: 10.1016/s0009-3084(99)00073-0. Chem Phys Lipids. 1999. PMID: 11001559 Review.
Cited by
-
A stretch of 17 amino acids in the prosaposin C terminus is critical for its binding to sortilin and targeting to lysosomes.J Histochem Cytochem. 2010 Mar;58(3):287-300. doi: 10.1369/jhc.2009.955203. Epub 2009 Nov 24. J Histochem Cytochem. 2010. PMID: 19934382 Free PMC article.
-
Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction.Lipids. 1998 Jun;33(6):601-5. doi: 10.1007/s11745-998-0246-2. Lipids. 1998. PMID: 9655376
-
Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity.J Lipid Res. 2015 Sep;56(9):1747-61. doi: 10.1194/jlr.M061036. Epub 2015 Jul 14. J Lipid Res. 2015. PMID: 26175473 Free PMC article.
-
Analysis of glucocerebrosidase activity using N-(1-[14C]hexanoyl)-D-erythroglucosylsphingosine demonstrates a correlation between levels of residual enzyme activity and the type of Gaucher disease.Biochem J. 1994 Oct 15;303 ( Pt 2)(Pt 2):377-82. doi: 10.1042/bj3030377. Biochem J. 1994. PMID: 7980395 Free PMC article.
-
Ligand extraction properties of the GM2 activator protein and its interactions with lipid vesicles.Biophys J. 2009 Jul 8;97(1):257-66. doi: 10.1016/j.bpj.2009.03.065. Biophys J. 2009. PMID: 19580763 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
