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Comparative Study
. 1992 Apr 17;577(2):347-50.
doi: 10.1016/0006-8993(92)90296-l.

Serotonergic influence on cholinergic-induced analgesia: differences in two inbred strains of mice

F Pavone  1 , S Fagioli
Affiliations
Comparative Study

Serotonergic influence on cholinergic-induced analgesia: differences in two inbred strains of mice

F Pavone et al. Brain Res. .

Abstract

C57BL/6 (C57) and DBA/2 (DBA) inbred mice showed different analgesic responses to cholinergic stimulation. The simultaneous administration of muscarinic and serotonergic agonists, oxotremorine and 5-methoxy-NN-dimethyltryptamine (5-MeODMT), lowered the antinociceptive effect of the cholinergic drug in DBA mice, while no effects were detectable in the C57 strain. These results suggest a strain-dependent behavioural effect of the interaction of cholinergic and serotonergic neuronal systems.

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