Regulatory functions of the lambda repressor reside in the amino-terminal domain
- PMID: 16068162
- DOI: 10.1038/279396a0
Regulatory functions of the lambda repressor reside in the amino-terminal domain
Abstract
The repressor of bacteriophage lambda is a protein containing two domains of approximately equal size. Fragments containing the amino-terminal domain of repressor bind specifically to lambda operator DNA and mediate positive and negative control of lambda transcription both in vitro and in vivo.
Similar articles
-
Single-chain repressors containing engineered DNA-binding domains of the phage 434 repressor recognize symmetric or asymmetric DNA operators.J Mol Biol. 1997 Mar 21;267(1):118-31. doi: 10.1006/jmbi.1996.0832. J Mol Biol. 1997. PMID: 9096211
-
Lambda repressor N-terminal DNA-binding domain as an assay for protein transmembrane segment interactions in vivo.J Mol Biol. 1998 Jul 31;280(5):799-810. doi: 10.1006/jmbi.1998.1893. J Mol Biol. 1998. PMID: 9671551
-
Lambda cI repressor mutants altered in transcriptional activation.J Mol Biol. 1994 Sep 9;242(1):23-36. doi: 10.1006/jmbi.1994.1554. J Mol Biol. 1994. PMID: 8078069
-
NMR structure and functional studies of the Mu repressor DNA-binding domain.Biochemistry. 1999 Jun 29;38(26):8367-76. doi: 10.1021/bi990530b. Biochemistry. 1999. PMID: 10387082
-
An aromatic stacking interaction between subunits helps mediate DNA sequence specificity: operator site discrimination by phage lambda cI repressor.J Mol Biol. 1997 Mar 28;267(2):403-17. doi: 10.1006/jmbi.1996.0869. J Mol Biol. 1997. PMID: 9096234
Cited by
-
Deletions within a hinge region of a specific DNA-binding protein.Proc Natl Acad Sci U S A. 1985 Apr;82(8):2301-5. doi: 10.1073/pnas.82.8.2301. Proc Natl Acad Sci U S A. 1985. PMID: 3887398 Free PMC article.
-
pH-dependent autocleavage of lambda repressor occurs in the operator-bound form: characterization of lambda repressor autocleavage.Biochem J. 2004 Apr 15;379(Pt 2):325-30. doi: 10.1042/BJ20031834. Biochem J. 2004. PMID: 14733611 Free PMC article.
-
Mutant lambda phage repressor with a specific defect in its positive control function.Proc Natl Acad Sci U S A. 1982 Apr;79(7):2236-9. doi: 10.1073/pnas.79.7.2236. Proc Natl Acad Sci U S A. 1982. PMID: 6212933 Free PMC article.
-
The sequence specificity of homeodomain-DNA interaction.Cell. 1988 Sep 23;54(7):1081-90. doi: 10.1016/0092-8674(88)90123-7. Cell. 1988. PMID: 3046753 Free PMC article.
-
The ClpX protease is essential for inactivating the CI master repressor and completing prophage induction in Staphylococcus aureus.Nat Commun. 2023 Oct 18;14(1):6599. doi: 10.1038/s41467-023-42413-0. Nat Commun. 2023. PMID: 37852980 Free PMC article.
LinkOut - more resources
Full Text Sources