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Review
. 2005 Jul;6(7):530-41.
doi: 10.1038/nrm1681.

Heparan sulphate proteoglycans: the sweet side of development

Udo Häcker  1 , Kent Nybakken, Norbert Perrimon
Affiliations
Review

Heparan sulphate proteoglycans: the sweet side of development

Udo Häcker et al. Nat Rev Mol Cell Biol. 2005 Jul.

Abstract

Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.

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