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. 2005 Aug;16(8):1006-11.
doi: 10.1089/hum.2005.16.1006.

Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice

Jae-Sung Bae  1 , Shigeki Furuya, Yoko Shinoda, Shogo Endo, Edward H Schuchman, Yoshio Hirabayashi, Hee Kyung Jin
Affiliations

Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice

Jae-Sung Bae et al. Hum Gene Ther. 2005 Aug.

Abstract

After transplantation, adult bone marrow-derived mesenchymal stem cells (BM-MSCs) may undergo transdifferentiation and/or cell fusion in response to new environments. However, the mechanism(s) that govern these cell fate switches remain unknown. Here we demonstrate that the pathology associated with murine Niemann-Pick disease type C (NP-C) cerebellum augments the ability of BM-MSCs to fuse with Purkinje neurons. The results suggest that the degenerative microenvironment of Purkinje neurons in the NP-C cerebellum modulates the cell fate switch of BM-MSCs via cell fusion.

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