Phthalate exposure during pregnancy and lower anogenital index in boys: wider implications for the general population?

Editorial

Richard M Sharpe. Environ Health Perspect. 2005 Aug.

. 2005 Aug;113(8):A504-5.

doi: 10.1289/ehp.113-a504.

No abstract available

Figures

Decrease in anogenital distance among male infants with prenatal phthalate exposure.
Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, Mao CS, Redmon JB, Ternand CL, Sullivan S, Teague JL; Study for Future Families Research Team. Swan SH, et al. Environ Health Perspect. 2005 Aug;113(8):1056-61. doi: 10.1289/ehp.8100. Environ Health Perspect. 2005. PMID: 16079079 Free PMC article.

1. Barlow NJ, McIntyre BS, Foster PMD. Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate. Toxicol Pathol. 2004;32:79–90. - PubMed
1. Ema M, Miyawaki E. Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy. Reprod Toxicol. 2001;15:189–194. - PubMed
1. Fisher JS, Macpherson S, Marchetti N, Sharpe RM. Human ‘testicular dysgenesis syndrome’: a possible model based on in-utero exposure of the rat to dibutyl phthalate. Hum Reprod. 2003;18:1383–1394. - PubMed
1. Gray LE, Jr, Ostby J, Furr J, Price M, Veeramachaneni DNR, Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci. 2000;58:350–365. - PubMed
1. Jorgensen N, Carlsen E, Nermoen I, Punab M, Suominen J, Andersen AG, et al. East-West gradient in semen qaulity in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland. Hum Reprod. 2002;17:2199–2208. - PubMed