Comment on

• Tumour biology: senescence in premalignant tumours.

  Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M, Benguría A, Zaballos A, Flores JM, Barbacid M, Beach D, Serrano M. Collado M, et al. Nature. 2005 Aug 4;436(7051):642. doi: 10.1038/436642a. Nature. 2005. PMID: 16079833
• Oncogene-induced senescence as an initial barrier in lymphoma development.

  Braig M, Lee S, Loddenkemper C, Rudolph C, Peters AH, Schlegelberger B, Stein H, Dörken B, Jenuwein T, Schmitt CA. Braig M, et al. Nature. 2005 Aug 4;436(7051):660-5. doi: 10.1038/nature03841. Nature. 2005. PMID: 16079837
• BRAFE600-associated senescence-like cell cycle arrest of human naevi.

  Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM, Majoor DM, Shay JW, Mooi WJ, Peeper DS. Michaloglou C, et al. Nature. 2005 Aug 4;436(7051):720-4. doi: 10.1038/nature03890. Nature. 2005. PMID: 16079850
• Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis.

  Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, Cordon-Cardo C, Pandolfi PP. Chen Z, et al. Nature. 2005 Aug 4;436(7051):725-30. doi: 10.1038/nature03918. Nature. 2005. PMID: 16079851 Free PMC article.