Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Aug 4;436(7051):642.
doi: 10.1038/436642a.

Tumour biology: senescence in premalignant tumours

Manuel Collado  1 , Jesús Gil, Alejo Efeyan, Carmen Guerra, Alberto J Schuhmacher, Marta Barradas, Alberto Benguría, Angel Zaballos, Juana M Flores, Mariano Barbacid, David Beach, Manuel Serrano
Affiliations
Free article

Tumour biology: senescence in premalignant tumours

Manuel Collado et al. Nature. .
Free article

Abstract

Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras, and show that senescent cells exist in premalignant tumours but not in malignant ones. Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnosis and prognosis of cancer.

PubMed Disclaimer

Comment in

  • Cancer: crime and punishment.
    Sharpless NE, DePinho RA. Sharpless NE, et al. Nature. 2005 Aug 4;436(7051):636-7. doi: 10.1038/436636a. Nature. 2005. PMID: 16079829 No abstract available.

MeSH terms