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Comparative Study
. 2005 Aug 22;518(2-3):221-6.
doi: 10.1016/j.ejphar.2005.06.001.

Adrenomedullin modulates COX-2 and HGF expression in reserpine-injuried gastric mucosa in the rat

Giuseppina Cantarella  1 , Giuseppa Martinez, Vincenza Maria Cutuli, Carla Loreto, Maria D'Alcamo, Agata Prato, Matilde Amico-Roxas, Renato Bernardini, Giuseppe Clementi
Affiliations
Comparative Study

Adrenomedullin modulates COX-2 and HGF expression in reserpine-injuried gastric mucosa in the rat

Giuseppina Cantarella et al. Eur J Pharmacol. .

Abstract

Here we show the increased hepatocyte growth factor (HGF) and cyclooxygenase-2 (COX-2) expression in gastric mucosa of rats which have developed a reserpine-induced ulcer. Such an increase of HGF and COX-2 expression was blunted in rats pretreated with adrenomedullin. Pretreatment with adrenomedullin and the adrenomedullin22-52 fragment did not result in changes of HGF and COX-2 expression, compared to the reserpine and adrenomedullin treated group. Pretreatment with adrenomedullin and the calcitonin gene-related peptide8-37 fragment (CGRP8-37) increased HGF and COX-2 expression, compared to the reserpine and adrenomedullin treated group. Our results suggest that the inhibitory effect of adrenomedullin on the expression of HGF and COX-2 is mediated by CGRP receptors.

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