Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Aug;116(2):419-22.
doi: 10.1016/j.jaci.2005.05.040.

The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection

Saurabh Mehandru  1 , Klara Tenner-Racz, Paul Racz, Martin Markowitz
Affiliations

The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection

Saurabh Mehandru et al. J Allergy Clin Immunol. 2005 Aug.

Abstract

It has become evident that the gastrointestinal tract is preferentially and profoundly depleted of CD4+ T cells during acute HIV-1 infection. The enhanced susceptibility of gastrointestinal lymphoid tissue to HIV-1 is in part due to the large complement of CCR5+ memory CD4+ T cells resident at this site. Here we summarize the recent findings demonstrating that the gastrointestinal tract plays a critical role in the pathogenesis of acute HIV-1 and simian immunodeficiency virus infections. Ongoing work in this field is likely to have a significant effect on HIV research in the near future.

PubMed Disclaimer

Substances