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Clinical Trial
. 2005 Oct;167(1-2):215-8.
doi: 10.1016/j.jneuroim.2005.07.001.

Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: reversal by glatiramer acetate

David Azoulay  1 , Veronika Vachapova, Boris Shihman, Ariel Miler, Arnon Karni
Affiliations
Clinical Trial

Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: reversal by glatiramer acetate

David Azoulay et al. J Neuroimmunol. 2005 Oct.

Abstract

Neuronal growth factors may exert a neuroprotective effect in multiple sclerosis (MS). We found reduced levels of brain-derived neurotrophic factors (BDNF) in the serum and CSF of relapsing-remitting MS patients, which was reversed by therapy with glatiramer acetate. BDNF may play a protective role in MS, and immunomodulation therapy, such as with glatiramer acetate, may enhance the action this mechanism.

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