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. 2005 Sep;12(9):822-3.
doi: 10.1038/nsmb971. Epub 2005 Aug 7.

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

Jason K Yano  1 , Mei-Hui Hsu, Keith J Griffin, C David Stout, Eric F Johnson
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Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

Jason K Yano et al. Nat Struct Mol Biol. 2005 Sep.

Abstract

Human microsomal cytochrome P450 2A6 (CYP2A6) contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. The CYP2A6 structure shows a compact, hydrophobic active site with one hydrogen bond donor, Asn297, that orients coumarin for regioselective oxidation. The inhibitor methoxsalen effectively fills the active site cavity without substantially perturbing the structure. The structure should aid the design of inhibitors to reduce smoking and tobacco-related cancers.

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  • Striving to stop smoking.
    [No authors listed] [No authors listed] Nat Struct Mol Biol. 2005 Sep;12(9):729. doi: 10.1038/nsmb0905-729. Nat Struct Mol Biol. 2005. PMID: 16142219 No abstract available.

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