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. 2005 Aug 17;127(32):11250-1.
doi: 10.1021/ja053335v.

Copper(II) acetate promoted intramolecular diamination of unactivated olefins

Thomas P Zabawa  1 , Dhanalakshmi Kasi, Sherry R Chemler
Affiliations

Copper(II) acetate promoted intramolecular diamination of unactivated olefins

Thomas P Zabawa et al. J Am Chem Soc. .

Abstract

A concise method for the synthesis of cyclic sulfamides and vicinal diamines is presented. This method is enabled by Cu(OAc)2 and demonstrates a new transformation for this metal. Both five- and six-membered vicinal diamine-containing heterocycles have been synthesized in good to excellent yields, and substrate-based asymmetric induction has been achieved. This is the first reported example of intramolecular diamination of olefins.

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