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. 1992 Jun 15;89(12):5381-3.
doi: 10.1073/pnas.89.12.5381.

Encoded combinatorial chemistry

S Brenner  1 , R A Lerner
Affiliations

Encoded combinatorial chemistry

S Brenner et al. Proc Natl Acad Sci U S A. .

Abstract

The diversity of chemical synthesis and the power of genetics are linked to provide a powerful, versatile method for drug screening. A process of alternating parallel combinatorial synthesis is used to encode individual members of a large library of chemicals with unique nucleotide sequences. After the chemical entity is bound to a target, the genetic tag can be amplified by replication and utilized for enrichment of the bound molecules by serial hybridization to a subset of the library. The nature of the chemical structure bound to the receptor is decoded by sequencing the nucleotide tag.

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