Comparative Study
doi: 10.1073/pnas.89.12.5680.
Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA
Affiliations
- PMID: 1608979
- PMCID: PMC49356
- DOI: 10.1073/pnas.89.12.5680
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Comparative Study
Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA
Proc Natl Acad Sci U S A.
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Abstract
Each aminoacyl-tRNA synthetase must functionally distinguish its cognate tRNAs from all others. We have determined the minimum number of changes required to transform a leucine amber suppressor tRNA to serine identity. Eight changes are required. These are located in the acceptor stem and in the D stem.
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