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Review
. 2005 Jul;62(1):1-15.
doi: 10.1111/j.1365-3083.2005.01634.x.

CD4+CD25+-regulatory T cells from mouse to man

K Wing  1 , E Suri-Payer, A Rudin
Affiliations
Free article
Review

CD4+CD25+-regulatory T cells from mouse to man

K Wing et al. Scand J Immunol. 2005 Jul.
Free article

Abstract

Immunological tolerance is one of the fundamental concepts of the immune system. During the past decade, CD4+CD25+-regulatory T cells have emerged as key players in the development of tolerance to autoantigens as well as to foreign antigens. Still many questions remain illusive regarding the basic properties of CD4+CD25+-regulatory T cells. This review aims to recapitulate some of the current understandings about the phenotype, function and clinical relevance of murine and human CD4+CD25+-regulatory T cells.

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