Review
doi: 10.1111/j.1365-3083.2005.01634.x.
CD4+CD25+-regulatory T cells from mouse to man
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- PMID: 16091121
- DOI: 10.1111/j.1365-3083.2005.01634.x
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Review
CD4+CD25+-regulatory T cells from mouse to man
Scand J Immunol.
2005 Jul.
Free article
Abstract
Immunological tolerance is one of the fundamental concepts of the immune system. During the past decade, CD4+CD25+-regulatory T cells have emerged as key players in the development of tolerance to autoantigens as well as to foreign antigens. Still many questions remain illusive regarding the basic properties of CD4+CD25+-regulatory T cells. This review aims to recapitulate some of the current understandings about the phenotype, function and clinical relevance of murine and human CD4+CD25+-regulatory T cells.
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