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. 2005 Aug;26(7):1824-31.

Regional lobar atrophy predicts memory impairment in multiple sclerosis

Ralph H B Benedict  1 , Robert Zivadinov, Dominic A Carone, Bianca Weinstock-Guttman, Jeff Gaines, Cosimo Maggiore, Jitendra Sharma, Maria-Antonietta Tomassi, Rohit Bakshi
Affiliations

Regional lobar atrophy predicts memory impairment in multiple sclerosis

Ralph H B Benedict et al. AJNR Am J Neuroradiol. 2005 Aug.

Abstract

Background and purpose: In recent studies, measures of whole brain atrophy were strongly correlated with neuropsychological testing, explaining more variance than measures of lesion burden in patients with multiple sclerosis. The relationship between regional lobar atrophy and cognitive impairment is yet to be examined. We endeavored to assess the clinical significance of regional lobar atrophy in multiple sclerosis.

Methods: In a cross-sectional study, we evaluated 31 patients with multiple sclerosis with brain MR imaging and neuropsychological testing. Impairment was determined by comparison with demographically matched healthy controls. MR imaging generated measures of lesion burden (fluid-attenuated inversion recovery hyperintense volume), general atrophy (brain parenchymal fraction), central atrophy (lateral ventricle volume), and lobar atrophy (regional brain parenchymal fraction of frontal, temporal, parietal, and occipital lobes in each hemisphere). Neuropsychological testing emphasized measures of processing speed and memory, because these are commonly affected in multiple sclerosis.

Results: Patients with multiple sclerosis showed significant atrophy and impairment on all neuropsychological tests. Regional atrophy accounted for the most variance in all regression models predicting memory performance. Left temporal atrophy was the primary predictor of auditory/verbal memory (partial r's = 0.55-0.61), and both left and right temporal atrophy predicted visual/spatial memory performance (partial r's = 0.51-0.67). Models predicting learning consistency retained frontal lobe atrophy measures (partial r's = 0.44-0.68). Central and general atrophy measures were the primary predictors in modeling processing speed (partial r's = 0.42-0.64).

Conclusion: Regional atrophy accounts for more variance than lesion burden, whole brain atrophy, or lateral ventricle volume in predicting multiple sclerosis-associated memory dysfunction.

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Figures

F<sc>ig</sc> 1.
Fig 1.
Regional brain atrophy measurement of the temporal lobes in a patient with secondary progressive multiple sclerosis. The top figure shows coronal 3D spoiled gradient-recalled acquisition in the steady state T1-weighted source image used for the segmentation of the temporal lobes. Panels A and C show the brain parenchyma–only and cerebrospinal fluid–only images of the right temporal lobe. Panels B and D show the same type of segmentation outputs in the left temporal lobe.
See this image and copyright information in PMC

References

    1. Knight RG, Devereux RC, Godfrey HPD. Psychosocial consequences of caring for a spouse with multiple sclerosis. J Clin Exp Neuropsychol 1997;19:7–19 - PubMed
    1. Rao SM, Leo GJ, Ellington L, Nauertz T, Bernardin L, Unveragt F. Cognitive dysfunction in multiple sclerosis. II. Impact on employment and social functioning. Neurology 1991;41:692–696 - PubMed
    1. Benedict RHB, Shapiro A, Priore RL, Miller C, Munschauer FE, Jacobs LD. Neuropsychological counseling improves social behavior in cognitively-impaired multiple sclerosis patients. Mult Scler 2001;6:391–396 - PubMed
    1. Amato MP, Ponziani G, Pracucci G, et al. Cognitive impairment in early-onset multiple sclerosis: pattern, predictors, and impact on everyday life in a 4-year follow-up. Arch Neurology 1995;52:168–172 - PubMed
    1. Grant I, McDonald WI, Trimble MR, Smith E, Reed R. Deficient learning and memory in early and middle phases of multiple sclerosis. J Neurology Neurosurg Psychiatry 1984;47:250–255 - PMC - PubMed

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