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. 2005 Aug 18;7(17):3781-3.
doi: 10.1021/ol0515964.

Enantioselective Brønsted acid catalyzed transfer hydrogenation: organocatalytic reduction of imines

Magnus Rueping  1 , Erli Sugiono, Cengiz Azap, Thomas Theissmann, Michael Bolte
Affiliations

Enantioselective Brønsted acid catalyzed transfer hydrogenation: organocatalytic reduction of imines

Magnus Rueping et al. Org Lett. .

Abstract

The first enantioselective Brønsted acid catalyzed reduction of imines has been developed. This new organocatalytic transfer hydrogenation of ketimines with Hantzsch dihydropyridine as the hydrogen source offers a mild method to various chiral amines with high enantioselectivity. The stereochemistry of the chiral amines can be rationalized by a stereochemical model derived from an X-ray crystal structure of a chiral BINOL phosphate catalyst. [reaction: see text]

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