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. 2005 Aug 18;7(17):3805-7.
doi: 10.1021/ol0514909.

The first Negishi cross-coupling reaction of two alkyl centers utilizing a Pd-N-heterocyclic carbene (NHC) catalyst

Niloufar Hadei  1 , Eric Assen B Kantchev, Christopher J O'Brien, Michael G Organ
Affiliations

The first Negishi cross-coupling reaction of two alkyl centers utilizing a Pd-N-heterocyclic carbene (NHC) catalyst

Niloufar Hadei et al. Org Lett. .

Abstract

The development of an NHC-based system capable of cross-coupling sp(3)-sp(3) centers in high yield has been a long-standing challenge. This communication describes the use of a Pd-NHC catalytic system that achieves room-temperature Negishi cross-couplings of unactivated, primary bromides and alkyl organozinc reagents with a variety of functionality. [reaction: see text]

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