Human T cell lymphotropic virus-associated leukemia/lymphoma
- PMID: 16093798
- PMCID: PMC2652726
- DOI: 10.1097/01.cco.0000174037.84903.fb
Human T cell lymphotropic virus-associated leukemia/lymphoma
Abstract
Purpose of review: This article summarizes the current pathophysiologic basis for human T cell lymphotropic virus-associated leukemia/lymphoma as well as past, present, and future therapeutic options.
Recent findings: New studies have been published on allogeneic stem cell transplantation, arsenic trioxide, and bortezomib for this condition.
Summary: Studies of the molecular biology of human T cell lymphotropic virus-1-induced T cell leukemia/lymphoma have defined a critical role for oncoprotein, Tax, and activation of nuclear factor kappaB transcription pathways, which have provided rational approaches to improved therapy for T cell leukemia/lymphoma as well as a model for other hematopoietic malignancies characterized by nuclear factor kappaB activation.
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