Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Sep;17(5):469-73.
doi: 10.1097/01.cco.0000174037.84903.fb.

Human T cell lymphotropic virus-associated leukemia/lymphoma

Lee Ratner  1
Affiliations
Review

Human T cell lymphotropic virus-associated leukemia/lymphoma

Lee Ratner. Curr Opin Oncol. 2005 Sep.

Abstract

Purpose of review: This article summarizes the current pathophysiologic basis for human T cell lymphotropic virus-associated leukemia/lymphoma as well as past, present, and future therapeutic options.

Recent findings: New studies have been published on allogeneic stem cell transplantation, arsenic trioxide, and bortezomib for this condition.

Summary: Studies of the molecular biology of human T cell lymphotropic virus-1-induced T cell leukemia/lymphoma have defined a critical role for oncoprotein, Tax, and activation of nuclear factor kappaB transcription pathways, which have provided rational approaches to improved therapy for T cell leukemia/lymphoma as well as a model for other hematopoietic malignancies characterized by nuclear factor kappaB activation.

PubMed Disclaimer

References

    1. Bazarbachi A, Ghez D, Lepelletier Y, et al. New therapeutic approaches for adult T-cell leukaemia. Lancet Oncol. 2004;5:664–672. This is an excellent recent review of treatment for ATLL. - PubMed
    1. Ratner L. Adult T cell leukemia lymphoma. Front Biosci. 2004;9:2852–2859. - PMC - PubMed
    1. Kannagi M, Harashima N, Kurihara K, et al. Adult T-cell leukemia: future pro-phylaxis and immunotherapy. Expert Rev Anticancer Ther. 2004;4:369–376. - PubMed
    1. Franchini G, Nicot C, Johnson JM. Seizing of T cells by human T-cell leukemia/lymphoma virus type 1. Adv Cancer Res. 2003;89:69–132. - PubMed
    1. Jeang K-T, Giam C-Z, Majone F, Aboud M. Life, death, and Tax: role of HTLV-I oncoprotein in genetic instability and cellular transformation. J Biol Chem. 2004;279:31991–31994. This is an excellent review of the Tax oncoprotein. - PubMed

Publication types

MeSH terms