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. 2005 Aug 11;436(7052):792.
doi: 10.1038/436792a.

Colorectal cancer: mutations in a signalling pathway

D Williams Parsons  1 , Tian-Li Wang, Yardena Samuels, Alberto Bardelli, Jordan M Cummins, Laura DeLong, Natalie Silliman, Janine Ptak, Steve Szabo, James K V Willson, Sanford Markowitz, Kenneth W Kinzler, Bert Vogelstein, Christoph Lengauer, Victor E Velculescu
Affiliations

Colorectal cancer: mutations in a signalling pathway

D Williams Parsons et al. Nature. .

Abstract

Protein kinases are enzymes that are important for controlling cellular growth and invasion, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention.

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