The action of iodinated kallikrein on the rat uterus
Affiliations
- PMID: 1609650
Item in Clipboard
The action of iodinated kallikrein on the rat uterus
Agents Actions Suppl.
1992.
Abstract
Iodinated kallikrein appeared inactive on synthetic substrates, was unable to liberate kinins from rat plasma, did not cause contraction of the rat uterus and did not potentiate bradykinin activity. After several doses of iodinated kallikrein were applied to the muscle, the contraction caused by kallikrein was blocked, but the response of the preparation to bradykinin was unaltered. If a double dose of kallikrein was applied, the contraction appeared again, and the response to bradykinin was also potentiated. These results support a kinin-mediated oxytocic action of kallikrein, and suggest a new interpretation for the mechanism of kallikrein desensitization in this preparation.
Similar articles
-
On the mechanism of rat uterus desensitization to kallikrein.Agents Actions Suppl. 1992;38 ( Pt 2):115-9. Agents Actions Suppl. 1992. PMID: 1462820
-
Kinins contribute to the contractile effects of rat glandular kallikrein on the isolated rat uterus.J Pharmacol Exp Ther. 1989 May;249(2):470-5. J Pharmacol Exp Ther. 1989. PMID: 2724135
-
Kallikrein-induced uterine contraction independent of kinin formation.Proc Natl Acad Sci U S A. 1981 Oct;78(10):6154-7. doi: 10.1073/pnas.78.10.6154. Proc Natl Acad Sci U S A. 1981. PMID: 6947218 Free PMC article.
-
Long-term infusion of kallikrein attenuates renal injury in Dahl salt-sensitive rats.Am J Hypertens. 1997 May;10(5 Pt 2):83S-88S. Am J Hypertens. 1997. PMID: 9160787 Review.
-
Kallikreins and kinins in inflammatory-like events in the reproductive tract.Pharmacol Res. 1997 Jun;35(6):537-40. doi: 10.1006/phrs.1997.0183. Pharmacol Res. 1997. PMID: 9356205 Review.