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. 2005 Aug 21;11(31):4886-90.
doi: 10.3748/wjg.v11.i31.4886.

There is no association between K469E ICAM-1 gene polymorphism and biliary atresia

Paisarn Vejchapipat  1 , Naruemol Jirapanakorn, Nutchanart Thawornsuk, Apiradee Theamboonlers, Voranush Chongsrisawat, Soottiporn Chittmittrapap, Yong Poovorawan
Affiliations

There is no association between K469E ICAM-1 gene polymorphism and biliary atresia

Paisarn Vejchapipat et al. World J Gastroenterol. .

Abstract

Aim: To determine whether there was an association between inter-cellular adhesion molecule-1 (ICAM-1) gene polymorphism and biliary atresia (BA), and to investigate the relationship between serum soluble ICAM-1 (sICAM-1) and clinical outcome in BA patients after surgical treatment.

Methods: Eighty-three BA patients and 115 normal controls were genotyped. K469E ICAM-1 polymorphism was analyzed using PCR assay. Serum sICAM-1 was determined using ELISA method from 72 BA patients. In order to evaluate the association between these variables and their clinical outcome, the patients were categorized into two groups: patients without jaundice and those with persistent jaundice.

Results: There were no significant differences between BA patients and controls in terms of gender, K469E ICAM-1 genotypes, and alleles. The proportion of patients having serum sICAM-1 >=3 500 ng/mL in persistent jaundice group was significantly higher than that in the other group. In addition, there was no association between K469E ICAM-1 polymorphism and the status of jaundice in BA patients after Kasai operation.

Conclusion: ICAM-1 possibly plays an important and active role in the disease progression. However, the process is not associated with genetic variation of K469E ICAM-1 polymorphism.

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