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. 2005 Aug 21;11(31):4908-11.
doi: 10.3748/wjg.v11.i31.4911.

Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis

Ji-Ren Yu  1 , Yi-Jun Wu, Qi Qin, Ke-Zheng Lu, Sheng Yan, Xiao-Sun Liu, Shu-Sen Zheng
Affiliations

Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis

Ji-Ren Yu et al. World J Gastroenterol. .

Abstract

Aim: To investigate the expression of cyclooxygenase-2 (COX-2) in gastric cancer and its relation with the liver metastasis and prognosis.

Methods: Expression of COX-2 mRNA and protein was examined in gastric cancer and its paired substantial normal tissue by semi-quantitative reverse transcription-polymerase chain reaction and immunohistochemistry. The relation between COX-2 expression and prognosis was investigated in 195 cases.

Results: The expression of COX-2 mRNA in gastric cancer tissue was significantly higher than that in normal tissue in 47 cases (w = 792, P<0.01). The COX-2 mRNA in pT3-4 tissue expressed higher than that in pT1-2 tissue (w = 204, P<0.05). The positive expression rate of COX-2 protein was 57.9% (113/195). The COX-2 expression was significantly related to histological type, lymphnode metastasis, venous invasion and liver metastasis (P<0.05). No relation was found between COX-2 expression and invasion depth, peritoneal metastasis and International Union against Cancer TNM stage. The multiple regression analysis showed that the COX-2 expression and venous invasion were obviously associated with liver metastasis (P<0.05). However, there was no significant correlation between COX-2 immunoreactivity and prognosis.

Conclusion: COX-2 may play an important role in the development of gastric cancer, and the over-expression of COX-2 protein may be a high risk factor for liver metastasis.

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Figures

Figure 1
Figure 1
Expression of COX-2 mRNA in gastric cancer. M: pUC19 DNA/MspI marker; lanes 1 and 2: gastric cancer tissues; lanes 3 and 4: matched normal gastric mucosal tissue.
Figure 2
Figure 2
Immunostaining of COX-2 in gastric cancer.
Figure 3
Figure 3
Overall survival curves of patients with gastric cancer.
See this image and copyright information in PMC

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