Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Aug 21;11(31):4908-11.
doi: 10.3748/wjg.v11.i31.4911.

Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis

Ji-Ren Yu  1 , Yi-Jun Wu, Qi Qin, Ke-Zheng Lu, Sheng Yan, Xiao-Sun Liu, Shu-Sen Zheng
Affiliations

Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis

Ji-Ren Yu et al. World J Gastroenterol. .

Abstract

Aim: To investigate the expression of cyclooxygenase-2 (COX-2) in gastric cancer and its relation with the liver metastasis and prognosis.

Methods: Expression of COX-2 mRNA and protein was examined in gastric cancer and its paired substantial normal tissue by semi-quantitative reverse transcription-polymerase chain reaction and immunohistochemistry. The relation between COX-2 expression and prognosis was investigated in 195 cases.

Results: The expression of COX-2 mRNA in gastric cancer tissue was significantly higher than that in normal tissue in 47 cases (w = 792, P<0.01). The COX-2 mRNA in pT3-4 tissue expressed higher than that in pT1-2 tissue (w = 204, P<0.05). The positive expression rate of COX-2 protein was 57.9% (113/195). The COX-2 expression was significantly related to histological type, lymphnode metastasis, venous invasion and liver metastasis (P<0.05). No relation was found between COX-2 expression and invasion depth, peritoneal metastasis and International Union against Cancer TNM stage. The multiple regression analysis showed that the COX-2 expression and venous invasion were obviously associated with liver metastasis (P<0.05). However, there was no significant correlation between COX-2 immunoreactivity and prognosis.

Conclusion: COX-2 may play an important role in the development of gastric cancer, and the over-expression of COX-2 protein may be a high risk factor for liver metastasis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Expression of COX-2 mRNA in gastric cancer. M: pUC19 DNA/MspI marker; lanes 1 and 2: gastric cancer tissues; lanes 3 and 4: matched normal gastric mucosal tissue.
Figure 2
Figure 2
Immunostaining of COX-2 in gastric cancer.
Figure 3
Figure 3
Overall survival curves of patients with gastric cancer.
See this image and copyright information in PMC

References

    1. Farrow DC, Vaughan TL, Hansten PD, Stanford JL, Risch HA, Gammon MD, Chow WH, Dubrow R, Ahsan H, Mayne ST, et al. Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev. 1998;7:97–102. - PubMed
    1. García-Rodríguez LA, Huerta-Alvarez C. Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs. Epidemiology. 2001;12:88–93. - PubMed
    1. Morgan G. Beneficial effects of NSAIDs in the gastrointestinal tract. Eur J Gastroenterol Hepatol. 1999;11:393–400. - PubMed
    1. Funkhouser EM, Sharp GB. Aspirin and reduced risk of esophageal carcinoma. Cancer. 1995;76:1116–1119. - PubMed
    1. Taketo MM. Cyclooxygenase-2 inhibitors in tumorigenesis (Part II) J Natl Cancer Inst. 1998;90:1609–1620. - PubMed

Publication types