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Comment
. 2005 Aug;8(2):91-3.
doi: 10.1016/j.ccr.2005.07.012.

A common pathway for genetic events leading to pheochromocytoma

Patrick H Maxwell  1
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A common pathway for genetic events leading to pheochromocytoma

Patrick H Maxwell. Cancer Cell. 2005 Aug.
Free article

Abstract

Mutations in VHL, RET, NF1, SDHB, SDHC, and SDHD can give rise to pheochromocytoma/paraganglioma. These different genetic lesions may all act by decreasing the activity of a 2-oxoglutarate-dependent oxygenase, SM-20/EglN3/PHD3, resulting in reduced apoptosis of neural crest cells during development.

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