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Case Reports
. 2005 Nov;99(11):871-3.
doi: 10.1016/j.trstmh.2005.06.009.

Recrudescence of imported falciparum malaria after quinine therapy: potential drug interaction with phenytoin

C Fabre  1 , J Criddle, D Nolder, J L Klein
Affiliations
Case Reports

Recrudescence of imported falciparum malaria after quinine therapy: potential drug interaction with phenytoin

C Fabre et al. Trans R Soc Trop Med Hyg. 2005 Nov.

Abstract

Quinine remains a reliable treatment for falciparum malaria in most parts of the world. We report recrudescence of imported Plasmodium falciparum malaria following quinine treatment in the context of concurrent phenytoin use. Supported by a subtherapeutic quinine level, we hypothesise that a drug interaction with phenytoin may compromise the efficacy of quinine in the treatment of malaria.

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